ZRdb KZFP & Repeats
Overview

The KZFP phylogenetic tree

Domain architecture, annotation depth, ChIP-seq coverage and primate evolution for every KZFP in the database — read the rings from the inside out.

Circular phylogenetic tree of KZFPs with annotation, ChIP-seq and evolution rings
Phylogenetic tree of KZFPs. Construction was partially based on the KRAB domain. The annotation score reflects the richness of UniProt annotation — KZFPs with more experimental data appear darker. ChIP-seq availability from Cistrome is marked with a black square. KRAB, ZF and SCAN domains use different coloured squares, with degenerate ZF in grey. Two colours in the outer ring reflect the time of emergence and changes in binding specificity. Hover to magnify; please refer to our article for details.

Reading the rings

Inner ring: KRAB / ZF / SCAN domains. Middle: annotation score and ChIP-seq presence. Outer: primate conservation of binding specificity.

Zoom to read labels

Move the pointer over the figure — a magnifier follows the cursor so branch labels stay legible at full resolution.

Go deeper

Search any KZFP by gene symbol to see its motifs, peaks and ranked repeat associations.